Stay Current, Stay Sharp

American College of Physicians urges caution when patients want to use cannabis/cannabinoids to treat chronic noncancer pain

The evidence is sparse regarding the use of cannabis or cannabinoids for chronic noncancer pain and this "advice" (which is different from a more rigid gui....

Comparable cure rates with oral gepotidacin and ceftriaxone + azithromycin for uncomplicated urogenital gonorrhea (EAGLE-1)

In this study, oral gepotidacin was comparable with intramuscular ceftriaxone plus oral azithromycin in treating patients with uncomplicated urogenital gon....

Immunoglobulin alone is noninferior to immunoglobulin plus aspirin for Kawasaki disease

This study found IVIG alone to be noninferior to IVIG plus high-dose aspirin for reducing coronary artery lesions in children with Kawasaki disease. The re....

Real-world data don't support new Alzheimer's disease diagnostic criteria

In this interesting analysis, new Alzheimer's disease diagnostic criteria and the amyloid cascade theory correctly predicts one-third of adults who ev....

Awake prone positioning improves survival without intubation in patients with COVID-19 and acute hypoxemic respiratory failure

A meta-analysis of individual participant data from 14 trials shows that APP improves survival and delays time to intubation in patients....

Amiloride is noninferior to spironolactone for resistant hypertension

This study found amiloride to be noninferior to spironolactone for lowering blood pressure in adults with resistant hypertension. Amiloride is less likely....

Bedtime vs morning administration of antihypertensives equally safe with no difference in adverse CVD risk (BedMed)

This is the second recent major clinical trial to find no difference in either the effectiveness or safety from the antihypertensive medication administrat....

Sound masking, cognitive behavior therapy, and patient education may help tinnitus symptoms

Patients seeking treatment for tinnitus can try a variety of approaches to minimize its effect on their day-to-day lives. Give them education on hearing pr....

Wound vacs are no better than usual care in promoting healing of surgical wounds

In this study, a wound vac was no better than usual care in improving healing or other outcomes in patients with surgical wounds healing by secondary inten....

The benefits of antenatal physical activity interventions to improve pregnancy outcomes are doubtful

The benefits of antenatal physical activity interventions to improve birth outcomes are in doubt because of insufficient rigorous research. Meta-analyses i....